There are many things that can trigger pain in your chest, and although it may be something as minor as indigestion, you should never ignore it. Heart Conditions: Chest pain may indicate something serious such as a heart attack, blocked heart vessels, inflamed heart muscles, a rare tear in the coronary artery, an infection of the sac, or mitral valve prolapse in which a heart valve fails to close properly. Lung Conditions: A bacterial or viral infection in the lungs can cause coughing and difficulty breathing that leads to chest pain. Lung infections, blood clots (pulmonary embolism), abscesses, and asthma also may cause chest pain as you breathe. Gastrointestinal: Pain in your chest can also arise from gastrointestinal conditions like acid reflux, esophageal disorders or hypersensitivity, peptic ulcers, a hernia, pancreatitis or gallbladder problems. Other Causes of Chest Pain: Bones, muscles, and nerves in the chest area can also cause pain with abnormalities. If you have a fracture or muscle strain in the rib area, it will likely cause chest pain whenever you try to take deep breaths. Anxiety and panic attacks can also cause chest pain and palpitations.